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How does repaglinide work?

  People with diabetes have a deficiency or absence of a hormone produced by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood. In type 2 diabetes the pancreas does not produce sufficient insulin. The cells of the body are also resistant to the low levels of insulin circulating in the blood. Insulin would normally make the cells remove sugar from the blood. This means in type 2 diabetes blood sugar levels can rise too high.

  Repaglinide works by acting on the cells in the pancreas that produce insulin. These cells are called beta cells. Repaglinide causes the beta cells to produce more insulin.

  Repaglinide is taken before meals to enhance insulin production during the meal. The enhanced insulin production starts about 30 minutes after taking the dose of repaglinide. This results in a blood sugar lowering effect throughout the meal, as would occur naturally in people who don't have diabetes.