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Cisapride Basic Information

  Cisapride is a third-generation benzamide which is used in human and veterinary medicine as a motility enhancer. Motility disorders of the gastrointestinal tract (GI) are a common clinical problem in pets. Postoperative ileus is a common and particularly difficult complication observed after abdominal surgery in horses. Cisapride was once used as a medicine to improve motility in human medicine, but it is no longer manufactured or used for this purpose.

  Cisapride activates the release of acetylcholine from the mesenteric plexus, which in turn stimulates smooth muscle GI. Cisapride is a serotonergic agonist. Cisapride may show activity on the smooth muscle through the GI tract. Anatomical differences between species may affect clinical efficacy. For example, cisapride is not usually used to manage the megaesophage in dogs because they do not have smooth muscle in the esophagus. Like cisapride, metoclopramide and domperidone are also drugs in the class of benzamides. Cisapride does not increase gastric acid secretion.