Pharmacological effects of Dexamethasone: 1. Anti-inflammatory effects: Dexamethasone reduces and prevents tissue response to inflammation, thereby reducing inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at sites of inflammation and inhibit phagocytosis, release of lysosomal enzymes, and synthesis and release of inflammatory chemical mediators.
2. Dexamethasone has immunosuppressive effects: including preventing or inhibiting cell-mediated immune responses, delaying allergic reactions, reducing the number of T lymphocytes, monocytes, eosinophils, and reducing immunoglobulins and cell surface receptors. Binding ability, and inhibit the synthesis and release of interleukin, thereby reducing the conversion of T lymphocytes to lymphoblasts and reducing the expansion of the primary immune response. It can reduce the passage of immune complexes through the basement membrane and reduce the concentration of complement components and immunoglobulins.
Dexamethasone is easily absorbed from the digestive tract. Its plasma T1/2 is 190 minutes, tissue T1/2 is 3 days, and intramuscular injection of dexamethasone sodium phosphate or dexamethasone acetate reaches blood concentration at 1 hour and 8 hours, respectively. Peak. Dexamethasone plasma protein binding rate is lower than other corticosteroids, Dexamethasone 0.75mg anti-inflammatory activity equivalent to 5mg prednisolone.
Pharmacological effects of Dexamethasone
