Clindamycin hydrochloride is mainly used for the treatment of infections caused by Gram-positive cocci and various anaerobic bacteria, treatment of joint, bone marrow, respiratory and skin soft tissue infections, as well as tonsillitis, pharyngitis, pneumonia, acne, gynecological inflammation, Endocarditis, empyema and other infections. Acne vulgaris is a kind of skin disease that is often seen in clinical practice. The cause of its pathogenesis has been studied, mainly by aerobic bacteria and anaerobic bacteria. The anaerobic bacteria are P. acnes. According to various data, the above-mentioned pathogens are within the antibacterial spectrum of clindamycin. The use of clindamycin gel for the treatment of acne vulgaris can achieve a cure rate of 93.3%; 2% clindamycin hydrochloride cream (oil-in-water type), can be used to treat vaginitis, good effect, no stimulation, high local drug concentration, can treat bacterial vaginitis.
Clindamycin hydrochloride is easy to dissolve, has a high distribution coefficient in the body, has few adverse reactions, and is less affected by daily diet. It can be formulated into various dosage forms such as tablets, injections, elixirs, gels, vaginal effervescent tablets. However, the biological half-life of the drug is short, about 3 hours, so the drug is administered 3-4 times a day. In order to reduce the number of administrations, maintain the stability of blood concentration, improve patient compliance, and improve the therapeutic effect, it has been slowly controlled. Related reports on release preparations.
Clinical application of clindamycin hydrochloride
