1. When used together with antacids such as sodium bicarbonate, Oxytetracycline hydrochloride can be reduced in absorption and activity is reduced due to increased pH in the stomach. Therefore, antacids should not be taken within 1-3 hours after taking this product.
2. A drug containing a metal ion such as calcium, magnesium or iron forms an insoluble complex with Oxytetracycline hydrochloride, which reduces the absorption of the product.
3. When used together with the general anesthetic methoxyflurane, Oxytetracycline hydrochloride enhances its nephrotoxicity.
4. Oxytetracycline hydrochloride can aggravate renal dysfunction when used with strong diuretics such as furosemide.
5. Oxytetracycline hydrochloride can aggravate liver damage when used with other hepatotoxic drugs such as anti-tumor drugs.
6. The hypolipidemic drug cholestyramine or colestipol can affect the absorption of Oxytetracycline hydrochloride and must be taken separately at intervals of several hours.
7. Oxytetracycline hydrochloride can reduce the effectiveness of birth control pills and increase the possibility of menstrual bleeding.
8. Oxytetracycline hydrochloride inhibits plasma prothrombin activity, so patients receiving anticoagulant therapy need to adjust the dose of anticoagulant.
The drug effect of Oxytetracycline hydrochloride
