Product name:Human IRAP ELISA Kit
Description:
IRAP (also known as LNPEP) was originally described as an insulin-responsive aminopeptidase found in GLUT4-containing vesicles , but later found to be a critical enzyme that regulates the expression and activity of several essential hormones and regulatory proteins, including the GLUT4 transporter . This membrane associated, zinc-dependent cystinyl aminopeptidase acts as both a receptor for angiotensin IV as well as the enzyme that catalyzes the synthesis of this essential hormone from its angiotensinogen precursor. IRAP catalyzes the hydrolysis of several peptide hormones, including oxytocin and vasopressin . Abnormal IRAP expression or activity is associated with several forms of cancer in humans, including renal and endometrial cancer .