Product name:Human TF ELISA Kit
Description:
Tissue Factor is an integral membrane-bound glycoprotein (47 kD) on SDS-PAGE that requires the presence of specific phospholipids to function. It serves as both the receptor and essential cofactor(s) for VII and VIIa in initiating cell surface procoagulant activity (PCA). Once Tissue Factor was understood to initiate the extrinsic pathway of coagulation (directly activating VII that in turn activates factor X). As a potent initiator of coagulation, TF is believed to have a critical function in hemostasis and thrombogenesis. Tissue Factor, while predominantly found in lung, brain, placenta and some neoplastic tissues (e.g. breast carcinoma, melanoma), a recent investigation has shown increased Tissue Factor levels in patients diagnosed with malignant solid tumor diseases.