Product name:Carmustine
CAS:154-93-8
Molecular Formula:C5H9Cl2N3O2
Formula Weight:214.05
Specification:100mg
Description:
Carmustine or BCNU (= 'bis-chloronitrosourea') is a mustard gas-related α-chloro-nitrosourea compound used as an alkylating agent in chemotherapy.
It is used in the treatment of several types of brain cancer (including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma and lymphoma (Hodgkin's and non-Hodgkin).
Carmustine is a yellowish crystalline powder. Melting point 30-32℃, melted into an oily liquid. Soluble in methanol and ethanol, the solubility is 150mg/ml in 50% ethanol and 4mg/ml in water. It is most stable in aqueous solutions of petroleum ether and pH4.
Carmustine has three synthetic routes :(1) ethylene imine is used as raw material to generate bi(beta-chloroethyl) urea through condensation with phosgene, and then Carmustine mustard is prepared by nitrification. (2) urea as raw material, through condensation, ring opening, chlorination, nitrosation; (3) carnitine mustard was obtained by using ethanolamine as raw material by a procedure similar to method (2). The first method only needs two steps to obtain the product, but the raw materials used are ethylene imine and phosphorescent drugs, labor protection and production equipment requirements are very high. The second method is easy to obtain and operate.