Product name:Histamine dihydrochloride
CAS:56-92-8
Molecular Formula:C5H11Cl2N3
Formula Weight:184.07
Specification:1g
Solubility:Soluble to 100 mM in water and to 100 mM in DMSO
Storage:Store at room temperature.
Biological Activity:Endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.
Description:Histamine dihydrochloride is used for sustained remission and to prevent recurrence after initial remission therapy in adult patients with acute myeloid leukemia (AML). The drug reduces the production of oxygens by autophagocytes, inhibits nicotinamide adenine dinucleoside phosphooxidase and prevents interleukin-2 from activating NK and T cells. The histamine dihydrochloride injection was approved on the basis that its complete response with interleukin-2 significantly reduced recurrence of AML in patients.