Product name:Hydroxymethyl resin
Specification:100g
Description:
Hydroxymethyl resin is ideal for the solid phase immobilization of carboxylic acid. Less cross-linking is observed than that with Merrifield resin during the attachment of diacids. Reaction with a suitable phosgene equivalent converts this resin to a support suitable for the immobilization of amines. The carbamate linker of hydroxymethyl polystyrene can be used as an equivalent of Cbz, is stable to a wide range of acidic, basic and reductive conditions. Methyl esters can be produced by transesterification with MeONa or Ti(OEt)4/C2H5CO2Me. Carboxamides are also accessible via Lewis acid catalyzed aminolysis. Highly pure ketopiperazines can be produced by the resin-bound alpha-amino acids.