Product name:Phytohemagglutinin PHA-M
CAS:9008-97-3
Specification:5mg
Description:
Phytohemagglutinin-M (PHA-M) is used for the stimulation of cell division in Iymphocyte cultures.
Phytohemagglutinin (PHA), the lectin extract from the red kidney bean (Phaseolus vulgaris), contains potent, cell agglutinating and mitogenic activities . PHA contains a family of five isolectins (LE , L E , L E ,4 0 3 1 2 2 LE , L E ) each being a tetramer held together by noncovalent forces.The subunits are of two different types, designated leucocyte reactive (L) and erythrocyte reactive (E). L has high affinity for Iymphocyte sur-face receptors but little for those of erythrocytes and is responsible for the mitogenic properties of the isolectins. E is responsible for the erythrocyte agglutinating properties. PHA-P is the protein form and PHA-M is the mucoprotein form of these isolectins .
PHA is used as a mitogen in Iymphocyte cultures . For the stimu- lation of cell prollferation in Iymphocyte cultures 2 ¨C 10g/ml PHA-M lyophilizate are recommended.